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Structure, Immunogenicity, and Protective Mechanism of an Engineered Enterovirus 71-Like Particle Vaccine Mimicking 80S Empty Capsid

Enterovirus 71 (EV71) is the major causative agent of severe hand, foot, and mouth disease, which affects millions of young children in the Asia-Pacific region annually. In this study, we engineered a novel EV71 virus-like particle (VLP) that lacks VP4 (therefore designated VLP(ΔVP4)) and investigat...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Wang, Xiaoli, Ku, Zhiqiang, Zhang, Xiang, Ye, Xiaohua, Chen, Jinhuan, Liu, Qingwei, Zhang, Wei, Zhang, Chao, Fu, Zhenglin, Jin, Xia, Cong, Yao, Huang, Zhong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5730765/
https://ncbi.nlm.nih.gov/pubmed/29070691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01330-17
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