Beta-Propiolactone Inactivation of Coxsackievirus A16 Induces Structural Alteration and Surface Modification of Viral Capsids

Beta-propiolactone (BPL) is an inactivating agent that is widely used in the vaccine industry. However, its effects on vaccine protein antigens and its mechanisms of action remain poorly understood. Here we present cryo-electron microscopy (cryo-EM) structures of BPL-treated coxsackievirus A16 (CVA1...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Fan, Chen, Ye, Xiaohua, Ku, Zhiqiang, Kong, Liangliang, Liu, Qingwei, Xu, Cong, Cong, Yao, Huang, Zhong
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2017
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5375664/
https://ncbi.nlm.nih.gov/pubmed/28148783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00038-17
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