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The celecoxib derivatives AR-12 and AR-14 induce autophagy and clear prion-infected cells from prions
Prion diseases are fatal infectious neurodegenerative disorders that affect both humans and animals. The autocatalytic conversion of the cellular prion protein (PrP(C)) into the pathologic isoform PrP(Sc) is a key feature in prion pathogenesis. AR-12 is an IND-approved derivative of celecoxib that d...
Gorde:
| Argitaratua izan da: | Sci Rep |
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| Egile Nagusiak: | , , , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Nature Publishing Group UK
2017
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5730578/ https://ncbi.nlm.nih.gov/pubmed/29242534 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17770-8 |
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