טוען...
The celecoxib derivatives AR-12 and AR-14 induce autophagy and clear prion-infected cells from prions
Prion diseases are fatal infectious neurodegenerative disorders that affect both humans and animals. The autocatalytic conversion of the cellular prion protein (PrP(C)) into the pathologic isoform PrP(Sc) is a key feature in prion pathogenesis. AR-12 is an IND-approved derivative of celecoxib that d...
שמור ב:
| הוצא לאור ב: | Sci Rep |
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| Main Authors: | , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Nature Publishing Group UK
2017
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5730578/ https://ncbi.nlm.nih.gov/pubmed/29242534 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17770-8 |
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