The celecoxib derivatives AR-12 and AR-14 induce autophagy and clear prion-infected cells from prions

Prion diseases are fatal infectious neurodegenerative disorders that affect both humans and animals. The autocatalytic conversion of the cellular prion protein (PrP(C)) into the pathologic isoform PrP(Sc) is a key feature in prion pathogenesis. AR-12 is an IND-approved derivative of celecoxib that d...

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Publicado no:Sci Rep
Main Authors: Abdulrahman, Basant A., Abdelaziz, Dalia, Thapa, Simrika, Lu, Li, Jain, Shubha, Gilch, Sabine, Proniuk, Stefan, Zukiwski, Alexander, Schatzl, Hermann M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5730578/
https://ncbi.nlm.nih.gov/pubmed/29242534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17770-8
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