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The celecoxib derivatives AR-12 and AR-14 induce autophagy and clear prion-infected cells from prions
Prion diseases are fatal infectious neurodegenerative disorders that affect both humans and animals. The autocatalytic conversion of the cellular prion protein (PrP(C)) into the pathologic isoform PrP(Sc) is a key feature in prion pathogenesis. AR-12 is an IND-approved derivative of celecoxib that d...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5730578/ https://ncbi.nlm.nih.gov/pubmed/29242534 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17770-8 |
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