The celecoxib derivatives AR-12 and AR-14 induce autophagy and clear prion-infected cells from prions

Por Abdulrahman, Basant A., Abdelaziz, Dalia, Thapa, Simrika, Lu, Li, Jain, Shubha, Gilch, Sabine, Proniuk, Stefan, Zukiwski, Alexander, Schatzl, Hermann M.
Publicado no Sci Rep (2017)

AR-12 Inhibits Chaperone Proteins Preventing Virus Replication and the Accumulation of Toxic Misfolded Proteins

Por Booth, Laurence, Roberts, Jane L, Ecroyd, Heath, Reid, St. Patrick, Proniuk, Stefan, Zukiwski, Alexander, Jacob, Abraham, Damonte, Elsa, Tuñón, María J, Dent, Paul
Publicado no J Clin Cell Immunol (2016)

ACTR-40. PHASE 2 SAFETY AND EFFICACY OF AR-67 (7-T-BUTYLDIMETHYLSILTYL-10-HYDROXYCAMPTOTHECIN) IN PATIENTS WITH RECURRENT GLIOBLASTOMA MULTIFORME (GBM) OR GLIOSARCOMA

Por Kumthekar, Priya, Raizer, Jeffrey, Cavaliere, Robert, Devoe, Craig, Jensen, Randy, Stieber, Volker, Runk, Tina, Grewal, Jai, Brownell, Elise, Zukiwski, Alex, Proniuk, Stefan, Arnold, Susanne, Vredenburgh, James
Publicado no Neuro Oncol (2019)

Multi-kinase inhibitors can associate with heat shock proteins through their NH(2)-termini by which they suppress chaperone function

Por Booth, Laurence, Shuch, Brian, Albers, Thomas, Roberts, Jane L., Tavallai, Mehrad, Proniuk, Stefan, Zukiwski, Alexander, Wang, Dasheng, Chen, Ching-Shih, Bottaro, Don, Ecroyd, Heath, Lebedyeva, Iryna O., Dent, Paul
Publicado no Oncotarget (2016)

AR-12 Inhibits Multiple Chaperones Concomitant With Stimulating Autophagosome Formation Collectively Preventing Virus Replication

Por BOOTH, LAURENCE, ROBERTS, JANE L., ECROYD, HEATH, TRITSCH, SARAH R., BAVARI, SINA, REID, ST. PATRICK, PRONIUK, STEFAN, ZUKIWSKI, ALEXANDER, JACOB, ABRAHAM, SEPÚLVEDA, CLAUDIA S., GIOVANNONI, FEDERICO, GARCÍA, CYBELE C., DAMONTE, ELSA, GONZÁLEZ-GALLEGO, JAVIER, TUÑÓN, MARÍA J., DENT, PAUL
Publicado no J Cell Physiol (2016)

Phase I study of onapristone, a type I antiprogestin, in female patients with previously treated recurrent or metastatic progesterone receptor-expressing cancers

Por Cottu, Paul H., Bonneterre, Jacques, Varga, Andrea, Campone, Mario, Leary, Alexandra, Floquet, Anne, Berton-Rigaud, Dominique, Sablin, Marie-Paule, Lesoin, Anne, Rezai, Keyvan, Lokiec, François M., Lhomme, Catherine, Bosq, Jacques, Bexon, Alice S., Gilles, Erard M., Proniuk, Stefan, Dieras, Veronique, Jackson, David M., Zukiwski, Alexander, Italiano, Antoine
Publicado no PLoS One (2018)