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Immunization of cervidized transgenic mice with multimeric deer prion protein induces self-antibodies that antagonize chronic wasting disease infectivity in vitro

Chronic wasting disease (CWD) is the most contagious prion disease. It is expanding rapidly in North America, was found recently in Europe, and the potential for transmission to humans cannot be excluded yet. We hypothesized that it is possible to prevent peripheral CWD infection and CWD prion shedd...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Abdelaziz, Dalia H., Thapa, Simrika, Abdulrahman, Basant, Lu, Li, Jain, Shikha, Schatzl, Hermann M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5585258/
https://ncbi.nlm.nih.gov/pubmed/28874781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11235-8
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