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Autophagy regulates exosomal release of prions in neuronal cells

Prions are protein-based infectious agents that autocatalytically convert the cellular prion protein PrP(C) to its pathological isoform PrP(Sc). Subsequent aggregation and accumulation of PrP(Sc) in nervous tissues causes several invariably fatal neurodegenerative diseases in humans and animals. Pri...

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Podrobná bibliografie
Vydáno v:J Biol Chem
Hlavní autoři: Abdulrahman, Basant A., Abdelaziz, Dalia H., Schatzl, Hermann M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995502/
https://ncbi.nlm.nih.gov/pubmed/29700113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000713
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