Constitutive Ras signaling and Ink4a/Arf inactivation cooperate during the development of B-ALL in mice

Despite recent advances in treatment, human precursor B-cell acute lymphoblastic leukemia (B-ALL) remains a challenging clinical entity. Recent genome-wide studies have uncovered frequent genetic alterations involving RAS pathway mutations and loss of the INK4A/ARF locus, suggesting their important...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Sewastianik, Tomasz, Jiang, Meng, Sukhdeo, Kumar, Patel, Sanjay S., Roberts, Kathryn, Kang, Yue, Alduaij, Ahmad, Dennis, Peter S., Lawney, Brian, Liu, Ruiyang, Song, Zeyuan, Xiong, Jessie, Zhang, Yunyu, Lemieux, Madeleine E., Pinkus, Geraldine S., Rich, Jeremy N., Weinstock, David M., Mullighan, Charles G., Sharpless, Norman E., Carrasco, Ruben D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5729631/
https://ncbi.nlm.nih.gov/pubmed/29296886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017012211
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