Constitutive Ras signaling and Ink4a/Arf inactivation cooperate during the development of B-ALL in mice

Despite recent advances in treatment, human precursor B-cell acute lymphoblastic leukemia (B-ALL) remains a challenging clinical entity. Recent genome-wide studies have uncovered frequent genetic alterations involving RAS pathway mutations and loss of the INK4A/ARF locus, suggesting their important...

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Bibliographic Details
Published in:Blood Adv
Main Authors: Sewastianik, Tomasz, Jiang, Meng, Sukhdeo, Kumar, Patel, Sanjay S., Roberts, Kathryn, Kang, Yue, Alduaij, Ahmad, Dennis, Peter S., Lawney, Brian, Liu, Ruiyang, Song, Zeyuan, Xiong, Jessie, Zhang, Yunyu, Lemieux, Madeleine E., Pinkus, Geraldine S., Rich, Jeremy N., Weinstock, David M., Mullighan, Charles G., Sharpless, Norman E., Carrasco, Ruben D.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2017
Subjects:
Lymphoid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5729631/
https://ncbi.nlm.nih.gov/pubmed/29296886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017012211
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