Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss

NOTCH1 is activated by mutation in more than 50% of human T-cell acute lymphoblastic leukemias (T-ALLs) and inhibition of Notch signaling causes cell-cycle/growth arrest, providing rationale for NOTCH1 as a therapeutic target. The tumor suppressor phosphatase and tensin homolog (PTEN) is also mutate...

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Bibliographic Details
Main Authors: Medyouf, Hind, Gao, Xiuhua, Armstrong, Florence, Gusscott, Samuel, Liu, Qing, Gedman, Amanda Larson, Matherly, Larry H., Schultz, Kirk R., Pflumio, Francoise, You, Mingjian James, Weng, Andrew P.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2010
Subjects:
Lymphoid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826229/
https://ncbi.nlm.nih.gov/pubmed/20008304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-04-214718
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