PTEN regulation by Akt–EGR1–ARF–PTEN axis

The PTEN tumour suppressor gene is induced by the early growth response 1 (EGR1) transcription factor, which also transactivates p53, p73, and p300/CBP as well as other proapoptotic and anti-cancer genes. Here, we describe a novel Akt–EGR1–alternate reading frame (ARF)–PTEN axis, in which PTEN activ...

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Autori principali: Yu, Jianxiu, Zhang, Sharon S, Saito, Kan, Williams, Scott, Arimura, Yutaka, Ma, Yuliang, Ke, Yuehai, Baron, Veronique, Mercola, Dan, Feng, Gen-Sheng, Adamson, Eileen, Mustelin, Tomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2633077/
https://ncbi.nlm.nih.gov/pubmed/19057511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.238
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