Deregulation of tumor suppressive ASXL1−PTEN/AKT axis in myeloid malignancies

Mutations of epigenetic regulators are pervasive in human tumors. ASXL1 is frequently mutated in myeloid malignancies. We previously found that ASXL1 forms together with BAP1 a complex that can deubiquitinylate mono-ubiquitinylated lysine 119 on histone H2A (H2AK119ub1), a Polycomb repressive mark....

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Vydáno v:J Mol Cell Biol
Hlavní autoři: Cao, Lei, Xia, Xianyou, Kong, Yu, Jia, Fengqin, Yuan, Bo, Li, Rui, Li, Qian, Wang, Yuxin, Cui, Mingrui, Dai, Zhongye, Zheng, Huimin, Christensen, Jesper, Zhou, Yuan, Wu, Xudong
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7749738/
https://ncbi.nlm.nih.gov/pubmed/32236560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjaa011
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