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Deregulation of tumor suppressive ASXL1−PTEN/AKT axis in myeloid malignancies
Mutations of epigenetic regulators are pervasive in human tumors. ASXL1 is frequently mutated in myeloid malignancies. We previously found that ASXL1 forms together with BAP1 a complex that can deubiquitinylate mono-ubiquitinylated lysine 119 on histone H2A (H2AK119ub1), a Polycomb repressive mark....
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | J Mol Cell Biol |
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| Prif Awduron: | , , , , , , , , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
Oxford University Press
2020
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7749738/ https://ncbi.nlm.nih.gov/pubmed/32236560 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjaa011 |
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