Loss of Asxl2 leads to myeloid malignancies in mice

ASXL2 is frequently mutated in acute myeloid leukaemia patients with t(8;21). However, the roles of ASXL2 in normal haematopoiesis and the pathogenesis of myeloid malignancies remain unknown. Here we show that deletion of Asxl2 in mice leads to the development of myelodysplastic syndrome (MDS)-like...

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Li, Jianping, He, Fuhong, Zhang, Peng, Chen, Shi, Shi, Hui, Sun, Yanling, Guo, Ying, Yang, Hui, Man, Na, Greenblatt, Sarah, Li, Zhaomin, Guo, Zhengyu, Zhou, Yuan, Wang, Lan, Morey, Lluis, Williams, Sion, Chen, Xi, Wang, Qun-Tian, Nimer, Stephen D., Yu, Peng, Wang, Qian-Fei, Xu, Mingjiang, Yang, Feng-Chun
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2017
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5472177/
https://ncbi.nlm.nih.gov/pubmed/28593990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15456
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