Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy

ASXL1 is frequently mutated in myeloid malignancies and is known to co-occur with other gene mutations. However, the molecular mechanisms underlying the leukemogenesis associated with ASXL1 and cooperating mutations remain to be elucidated. Here, we report that Asxl1 loss cooperated with haploinsuff...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Zhang, Peng, He, Fuhong, Bai, Jie, Yamamoto, Shohei, Chen, Shi, Zhang, Lin, Sheng, Mengyao, Zhang, Lei, Guo, Ying, Man, Na, Yang, Hui, Wang, Suyun, Cheng, Tao, Nimer, Stephen D., Zhou, Yuan, Xu, Mingjiang, Wang, Qian-Fei, Yang, Feng-Chun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6264643/
https://ncbi.nlm.nih.gov/pubmed/30226831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI121366
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