Nf1 haploinsufficiency alters myeloid lineage commitment and function, leading to deranged skeletal homeostasis

While nullizygous loss of NF1 leads to myeloid malignancies, haploinsufficient loss of NF1 (Nf1) has been shown to contribute to osteopenia and osteoporosis which occurs in approximately 50 percent of neurofibromatosis type 1 (NF1) patients. Bone marrow mononuclear cells of haploinsufficient NF1 pat...

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Publicado en:J Bone Miner Res
Autores principales: Rhodes, Steven D., Yang, Hao, Dong, Ruizhi, Menon, Keshav, He, Yongzheng, Li, Zhaomin, Chen, Shi, Staser, Karl W., Jiang, Li, Wu, Xiaohua, Yang, Xianlin, Peng, Xianghong, Mohammad, Khalid S., Guise, Theresa A., Xu, Mingjiang, Yang, Feng-Chun
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5441523/
https://ncbi.nlm.nih.gov/pubmed/25917016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2538
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