Nf1 haploinsufficiency alters myeloid lineage commitment and function, leading to deranged skeletal homeostasis

While nullizygous loss of NF1 leads to myeloid malignancies, haploinsufficient loss of NF1 (Nf1) has been shown to contribute to osteopenia and osteoporosis which occurs in approximately 50 percent of neurofibromatosis type 1 (NF1) patients. Bone marrow mononuclear cells of haploinsufficient NF1 pat...

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Библиографические подробности
Опубликовано в: :J Bone Miner Res
Главные авторы: Rhodes, Steven D., Yang, Hao, Dong, Ruizhi, Menon, Keshav, He, Yongzheng, Li, Zhaomin, Chen, Shi, Staser, Karl W., Jiang, Li, Wu, Xiaohua, Yang, Xianlin, Peng, Xianghong, Mohammad, Khalid S., Guise, Theresa A., Xu, Mingjiang, Yang, Feng-Chun
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5441523/
https://ncbi.nlm.nih.gov/pubmed/25917016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2538
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