Hyperactive RAS/PI3-K/MAPK Signaling Cascade in Migration and Adhesion of Nf1 Haploinsufficient Mesenchymal Stem/Progenitor Cells

Neurofibromatosis type 1 (NF1) is an autosomal dominant disease caused by mutations in the NF1 tumor suppressor gene, which affect approximately 1 out of 3000 individuals. Patients with NF1 suffer from a range of malignant and nonmalignant manifestations such as plexiform neurofibromas and skeletal...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Zhou, Yuan, He, Yongzheng, Sharma, Richa, Xing, Wen, Estwick, Selina A., Wu, Xiaohua, Rhodes, Steven D., Xu, Mingjiang, Yang, Feng-Chun
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490447/
https://ncbi.nlm.nih.gov/pubmed/26039236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms160612345
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