Loss of ASXL1 in the bone marrow niche dysregulates hematopoietic stem and progenitor cell fates

Somatic or de novo mutations of Additional sex combs-like 1 (ASXL1) frequently occur in patients with myeloid malignancies or Bohring-Opitz syndrome, respectively. We have reported that global loss of Asxl1 leads to the development of myeloid malignancies and impairs bone marrow stromal cell (BMSC)...

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Bibliografiska uppgifter
I publikationen:Cell Discov
Huvudupphovsmän: Zhang, Peng, Chen, Zizhen, Li, Rong, Guo, Ying, Shi, Hui, Bai, Jie, Yang, Hui, Sheng, Mengyao, Li, Zhaomin, Li, Zhuo, Li, Jianping, Chen, Shi, Yuan, Weiping, Cheng, Tao, Xu, Mingjiang, Zhou, Yuan, Yang, Feng-Chun
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5802628/
https://ncbi.nlm.nih.gov/pubmed/29423272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41421-017-0004-z
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