Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice

Dual inactivation of PTEN and INK4a/ARF tumor suppressor genes is a common feature observed in a broad spectrum of human cancer types. To validate functional collaboration between these genes in tumor suppression, we examined the biological consequences of Pten and/or Ink4a/Arf deficiency in cells a...

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Detalhes bibliográficos
Main Authors: You, Mingjian James, Castrillon, Diego H., Bastian, Boris C., O'Hagan, Rónán C., Bosenberg, Marcus W., Parsons, Ramon, Chin, Lynda, DePinho, Ronald A.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC122212/
https://ncbi.nlm.nih.gov/pubmed/11818530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.022632099
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