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Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model

Epidemiological studies support a link between melanoma risk and UV exposure early in life, yet the molecular targets of UV's mutagenic actions are not known. By using well characterized murine models of melanoma, we provide genetic and molecular evidence that identifies components of the Rb pa...

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Autors principals: Kannan, Karuppiah, Sharpless, Norman E., Xu, Jin, O'Hagan, Ronan C., Bosenberg, Marcus, Chin, Lynda
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2003
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC298754/
https://ncbi.nlm.nih.gov/pubmed/12538879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0336397100
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