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Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse

The Rb/p16(Ink4a) and p53/p19Arf tumor suppressor pathways have been linked to diverse cancer-relevant processes, including those governing the cellular responses to telomere dysfunction. In this study, we sought to provide direct genetic evidence of a role for the Ink4a/Arf tumor suppressor gene, e...

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Main Authors: Khoo, Christine M., Carrasco, Daniel R., Bosenberg, Marcus W., Paik, Ji-Hye, DePinho, Ronald A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1820686/
https://ncbi.nlm.nih.gov/pubmed/17360455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700093104
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