ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence

Inactivation of the p53 pathway represents the most common molecular defect of human cancer. But in the setting of melanoma, a highly aggressive and invariably fatal malignancy in its advanced disseminated form, mutation/deletion of p53 is relatively rare, whereas its positive regulator ARF is often...

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Main Authors: Ha, Linan, Ichikawa, Takeshi, Anver, Miriam, Dickins, Ross, Lowe, Scott, Sharpless, Norman E., Krimpenfort, Paul, DePinho, Ronald A., Bennett, Dorothy C., Sviderskaya, Elena V., Merlino, Glenn
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2007
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1904138/
https://ncbi.nlm.nih.gov/pubmed/17576930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611638104
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