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Ink4a/Arf loss promotes tumor recurrence following Ras inhibition
Aberrant activation of rat sarcoma (Ras) signaling contributes to the development of a variety of human cancers, including gliomas. To determine the dependence of high-grade gliomas on continued Ras signaling, we developed a doxycycline-regulated Kirsten Ras (KRas) glioma mouse model. We previously...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3245997/ https://ncbi.nlm.nih.gov/pubmed/22015595 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nor184 |
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