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Activated MEK cooperates with Ink4a/Arf loss or Akt activation to induce gliomas in vivo
The RAS/RAF mitogen activated protein kinase pathway (MAPK) is highly active in many tumor types including the majority of high-grade gliomas and expression of activated RAS or RAF in neural progenitor cells combined with either AKT activation or Ink4a/Arf loss leads to the development of high-grade...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2010
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4109988/ https://ncbi.nlm.nih.gov/pubmed/21057530 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.513 |
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