Activated BRAF induces gliomas in mice when combined with Ink4a/Arf loss or Akt activation

Mutations in receptor tyrosine kinase (RTK) growth factor receptors (EGFR, PDGFR, MET and ERBB2), which result in downstream activation of the RAS/RAF/MEK/ERK mitogen-activated protein kinase (MAPK) pathway and PI(3)K/AKT pathway, are found in almost all high grade gliomas and MAPK signaling is nece...

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Bibliographic Details
Main Authors: Robinson, James P., VanBrocklin, Matthew W., Guilbeault, Adam R., Signorelli, Denise L., Brandner, Sebastian, Holmen, Sheri L.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109991/
https://ncbi.nlm.nih.gov/pubmed/19855433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.333
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