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Activated BRAF induces gliomas in mice when combined with Ink4a/Arf loss or Akt activation
Mutations in receptor tyrosine kinase (RTK) growth factor receptors (EGFR, PDGFR, MET and ERBB2), which result in downstream activation of the RAS/RAF/MEK/ERK mitogen-activated protein kinase (MAPK) pathway and PI(3)K/AKT pathway, are found in almost all high grade gliomas and MAPK signaling is nece...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4109991/ https://ncbi.nlm.nih.gov/pubmed/19855433 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.333 |
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