Ink4a/Arf loss promotes tumor recurrence following Ras inhibition

Aberrant activation of rat sarcoma (Ras) signaling contributes to the development of a variety of human cancers, including gliomas. To determine the dependence of high-grade gliomas on continued Ras signaling, we developed a doxycycline-regulated Kirsten Ras (KRas) glioma mouse model. We previously...

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Bibliografske podrobnosti
Main Authors: VanBrocklin, Matthew W., Robinson, James P., Lastwika, Kristin J., McKinney, Andrea J., Gach, H. Michael, Holmen, Sheri L.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2012
Teme:
Basic and Translational Investigations
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245997/
https://ncbi.nlm.nih.gov/pubmed/22015595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nor184
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