Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice

It is known that transient receptor potential ankyrin 1 (TRPA1) channels, expressed by nociceptors, contribute to neuropathic pain. Here we show that TRPA1 is also expressed in Schwann cells. We found that in mice with partial sciatic nerve ligation, TRPA1 silencing in nociceptors attenuated mechani...

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Veröffentlicht in:Nat Commun
Hauptverfasser: De Logu, Francesco, Nassini, Romina, Materazzi, Serena, Carvalho Gonçalves, Muryel, Nosi, Daniele, Rossi Degl’Innocenti, Duccio, Marone, Ilaria M., Ferreira, Juliano, Li Puma, Simone, Benemei, Silvia, Trevisan, Gabriela, Souza Monteiro de Araújo, Daniel, Patacchini, Riccardo, Bunnett, Nigel W., Geppetti, Pierangelo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5709495/
https://ncbi.nlm.nih.gov/pubmed/29192190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01739-2
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