Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice

It is known that transient receptor potential ankyrin 1 (TRPA1) channels, expressed by nociceptors, contribute to neuropathic pain. Here we show that TRPA1 is also expressed in Schwann cells. We found that in mice with partial sciatic nerve ligation, TRPA1 silencing in nociceptors attenuated mechani...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: De Logu, Francesco, Nassini, Romina, Materazzi, Serena, Carvalho Gonçalves, Muryel, Nosi, Daniele, Rossi Degl’Innocenti, Duccio, Marone, Ilaria M., Ferreira, Juliano, Li Puma, Simone, Benemei, Silvia, Trevisan, Gabriela, Souza Monteiro de Araújo, Daniel, Patacchini, Riccardo, Bunnett, Nigel W., Geppetti, Pierangelo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5709495/
https://ncbi.nlm.nih.gov/pubmed/29192190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01739-2
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