Pharmacological inhibition of the transcription factor PU.1 in leukemia

The transcription factor PU.1 is often impaired in patients with acute myeloid leukemia (AML). Here, we used AML cells that already had low PU.1 levels and further inhibited PU.1 using either RNA interference or, to our knowledge, first-in-class small-molecule inhibitors of PU.1 that we developed sp...

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Publicat a:J Clin Invest
Autors principals: Antony-Debré, Iléana, Paul, Ananya, Leite, Joana, Mitchell, Kelly, Kim, Hye Mi, Carvajal, Luis A., Todorova, Tihomira I., Huang, Kenneth, Kumar, Arvind, Farahat, Abdelbasset A., Bartholdy, Boris, Narayanagari, Swathi-Rao, Chen, Jiahao, Ambesi-Impiombato, Alberto, Ferrando, Adolfo A., Mantzaris, Ioannis, Gavathiotis, Evripidis, Verma, Amit, Will, Britta, Boykin, David W., Wilson, W. David, Poon, Gregory M.K., Steidl, Ulrich
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5707147/
https://ncbi.nlm.nih.gov/pubmed/29083320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92504
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