Pharmacological inhibition of the transcription factor PU.1 in leukemia

The transcription factor PU.1 is often impaired in patients with acute myeloid leukemia (AML). Here, we used AML cells that already had low PU.1 levels and further inhibited PU.1 using either RNA interference or, to our knowledge, first-in-class small-molecule inhibitors of PU.1 that we developed sp...

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Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Antony-Debré, Iléana, Paul, Ananya, Leite, Joana, Mitchell, Kelly, Kim, Hye Mi, Carvajal, Luis A., Todorova, Tihomira I., Huang, Kenneth, Kumar, Arvind, Farahat, Abdelbasset A., Bartholdy, Boris, Narayanagari, Swathi-Rao, Chen, Jiahao, Ambesi-Impiombato, Alberto, Ferrando, Adolfo A., Mantzaris, Ioannis, Gavathiotis, Evripidis, Verma, Amit, Will, Britta, Boykin, David W., Wilson, W. David, Poon, Gregory M.K., Steidl, Ulrich
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5707147/
https://ncbi.nlm.nih.gov/pubmed/29083320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92504
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