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Pharmacologic efficacy of PU.1 inhibition by heterocyclic dications: a mechanistic analysis
Heterocyclic dications are receiving increasing attention as targeted inhibitors of transcription factors. While many dications act as purely competitive inhibitors, some fail to displace protein efficiently at drug concentrations expected to saturate their DNA target. To achieve a mechanistic under...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4872103/ https://ncbi.nlm.nih.gov/pubmed/27079976 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw229 |
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