Structure-dependent inhibition of the ETS-family transcription factor PU.1 by novel heterocyclic diamidines

ETS transcription factors mediate a wide array of cellular functions and are attractive targets for pharmacological control of gene regulation. We report the inhibition of the ETS-family member PU.1 with a panel of novel heterocyclic diamidines. These diamidines are derivatives of furamidine (DB75)...

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Main Authors: Munde, Manoj, Wang, Shuo, Kumar, Arvind, Stephens, Chad E., Farahat, Abdelbasset A., Boykin, David W., Wilson, W. David, Poon, Gregory M. K.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2014
Assuntos:
Synthetic Biology and Chemistry
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3902942/
https://ncbi.nlm.nih.gov/pubmed/24157839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt955
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