Targeting the DNA-binding activity of the human ERG transcription factor using new heterocyclic dithiophene diamidines

Direct modulation of gene expression by targeting oncogenic transcription factors is a new area of research for cancer treatment. ERG, an ETS-family transcription factor, is commonly over-expressed or translocated in leukaemia and prostate carcinoma. In this work, we selected the di-(thiophene-pheny...

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Hauptverfasser: Nhili, Raja, Peixoto, Paul, Depauw, Sabine, Flajollet, Sébastien, Dezitter, Xavier, Munde, Manoj M., Ismail, Mohamed A., Kumar, Arvind, Farahat, Abdelbasset A., Stephens, Chad E., Duterque-Coquillaud, Martine, David Wilson, W., Boykin, David W., David-Cordonnier, Marie-Hélène
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2013
Schlagworte:
Gene Regulation, Chromatin and Epigenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3592449/
https://ncbi.nlm.nih.gov/pubmed/23093599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks971
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