Heterocyclic Diamidine DNA ligands as HOXA9 Transcription Factor Inhibitors: Design, Molecular Evaluation and Cellular Consequences in HOXA9-Dependant Leukemia Cell Model.

Most transcription factors were for a long time considered as undruggable targets due to the absence of binding pockets for direct targeting. HOXA9, implicated in acute myeloid leukemia, is one of them. To date, only indirect targeting of HOXA9 expression or multi-target HOX/PBX protein/protein inte...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:J Med Chem
المؤلفون الرئيسيون: Depauw, Sabine, Lambert, Mélanie, Jambon, Samy, Paul, Ananya, Peixoto, Paul, Nhili, Raja, Morongiu, Laura, Figeac, Martin, Dassi, Christelle, Paul-Constant, Charles, Billoré, Benjamin, Kumar, Arvind, Farahat, Abdelbasset A., Ismail, Mohamed A., Mineva, Ekaterina, Sweat, Daniel P., Stephens, Chad E., Boykin, David W., Wilson, W. David, David-Cordonnier, Marie-Hélène
التنسيق: Artigo
اللغة:Inglês
منشور في: 2019
الموضوعات:
Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561105/
https://ncbi.nlm.nih.gov/pubmed/30645099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01448
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