Heterocyclic Diamidine DNA ligands as HOXA9 Transcription Factor Inhibitors: Design, Molecular Evaluation and Cellular Consequences in HOXA9-Dependant Leukemia Cell Model.

Most transcription factors were for a long time considered as undruggable targets due to the absence of binding pockets for direct targeting. HOXA9, implicated in acute myeloid leukemia, is one of them. To date, only indirect targeting of HOXA9 expression or multi-target HOX/PBX protein/protein inte...

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Détails bibliographiques
Publié dans:J Med Chem
Auteurs principaux: Depauw, Sabine, Lambert, Mélanie, Jambon, Samy, Paul, Ananya, Peixoto, Paul, Nhili, Raja, Morongiu, Laura, Figeac, Martin, Dassi, Christelle, Paul-Constant, Charles, Billoré, Benjamin, Kumar, Arvind, Farahat, Abdelbasset A., Ismail, Mohamed A., Mineva, Ekaterina, Sweat, Daniel P., Stephens, Chad E., Boykin, David W., Wilson, W. David, David-Cordonnier, Marie-Hélène
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561105/
https://ncbi.nlm.nih.gov/pubmed/30645099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01448
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