Heterocyclic Diamidine DNA ligands as HOXA9 Transcription Factor Inhibitors: Design, Molecular Evaluation and Cellular Consequences in HOXA9-Dependant Leukemia Cell Model.

Most transcription factors were for a long time considered as undruggable targets due to the absence of binding pockets for direct targeting. HOXA9, implicated in acute myeloid leukemia, is one of them. To date, only indirect targeting of HOXA9 expression or multi-target HOX/PBX protein/protein inte...

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Publicat a:J Med Chem
Autors principals: Depauw, Sabine, Lambert, Mélanie, Jambon, Samy, Paul, Ananya, Peixoto, Paul, Nhili, Raja, Morongiu, Laura, Figeac, Martin, Dassi, Christelle, Paul-Constant, Charles, Billoré, Benjamin, Kumar, Arvind, Farahat, Abdelbasset A., Ismail, Mohamed A., Mineva, Ekaterina, Sweat, Daniel P., Stephens, Chad E., Boykin, David W., Wilson, W. David, David-Cordonnier, Marie-Hélène
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561105/
https://ncbi.nlm.nih.gov/pubmed/30645099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01448
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