Pharmacologic efficacy of PU.1 inhibition by heterocyclic dications: a mechanistic analysis

Heterocyclic dications are receiving increasing attention as targeted inhibitors of transcription factors. While many dications act as purely competitive inhibitors, some fail to displace protein efficiently at drug concentrations expected to saturate their DNA target. To achieve a mechanistic under...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Stephens, Dominique C., Kim, Hye Mi, Kumar, Arvind, Farahat, Abdelbasset A., Boykin, David W., K. Poon, Gregory M.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
Fag:
Chemical Biology and Nucleic Acid Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872103/
https://ncbi.nlm.nih.gov/pubmed/27079976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw229
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