Pharmacological inhibition of the transcription factor PU.1 in leukemia

The transcription factor PU.1 is often impaired in patients with acute myeloid leukemia (AML). Here, we used AML cells that already had low PU.1 levels and further inhibited PU.1 using either RNA interference or, to our knowledge, first-in-class small-molecule inhibitors of PU.1 that we developed sp...

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Опубликовано в: :J Clin Invest
Главные авторы: Antony-Debré, Iléana, Paul, Ananya, Leite, Joana, Mitchell, Kelly, Kim, Hye Mi, Carvajal, Luis A., Todorova, Tihomira I., Huang, Kenneth, Kumar, Arvind, Farahat, Abdelbasset A., Bartholdy, Boris, Narayanagari, Swathi-Rao, Chen, Jiahao, Ambesi-Impiombato, Alberto, Ferrando, Adolfo A., Mantzaris, Ioannis, Gavathiotis, Evripidis, Verma, Amit, Will, Britta, Boykin, David W., Wilson, W. David, Poon, Gregory M.K., Steidl, Ulrich
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2017
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5707147/
https://ncbi.nlm.nih.gov/pubmed/29083320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92504
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