Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia

Modest transcriptional changes caused by genetic or epigenetic mechanisms are frequent in human cancer. Although loss or near-complete loss of the hematopoietic transcription factor PU.1 induces acute myeloid leukemia (AML) in mice, a similar degree of PU.1 impairment is exceedingly rare in human AM...

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Pubblicato in:Nat Med
Autori principali: Will, Britta, Vogler, Thomas O., Narayanagari, Swathi, Bartholdy, Boris, Todorova, Tihomira I., da Silva Ferreira, Mariana, Chen, Jiahao, Yu, Yiting, Mayer, Jillian, Barreyro, Laura, Carvajal, Luis, Ben Neriah, Daniela, Roth, Michael, van Oers, Johanna, Schaetzlein, Sonja, McMahon, Christine, Edelmann, Winfried, Verma, Amit, Steidl, Ulrich
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5144917/
https://ncbi.nlm.nih.gov/pubmed/26343801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3936
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