Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia

Modest transcriptional changes caused by genetic or epigenetic mechanisms are frequent in human cancer. Although loss or near-complete loss of the hematopoietic transcription factor PU.1 induces acute myeloid leukemia (AML) in mice, a similar degree of PU.1 impairment is exceedingly rare in human AM...

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Bibliografiset tiedot
Julkaisussa:Nat Med
Päätekijät: Will, Britta, Vogler, Thomas O., Narayanagari, Swathi, Bartholdy, Boris, Todorova, Tihomira I., da Silva Ferreira, Mariana, Chen, Jiahao, Yu, Yiting, Mayer, Jillian, Barreyro, Laura, Carvajal, Luis, Ben Neriah, Daniela, Roth, Michael, van Oers, Johanna, Schaetzlein, Sonja, McMahon, Christine, Edelmann, Winfried, Verma, Amit, Steidl, Ulrich
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2015
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5144917/
https://ncbi.nlm.nih.gov/pubmed/26343801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3936
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