Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia

Modest transcriptional changes caused by genetic or epigenetic mechanisms are frequent in human cancer. Although loss or near-complete loss of the hematopoietic transcription factor PU.1 induces acute myeloid leukemia (AML) in mice, a similar degree of PU.1 impairment is exceedingly rare in human AM...

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Detalhes bibliográficos
Publicado no:Nat Med
Main Authors: Will, Britta, Vogler, Thomas O., Narayanagari, Swathi, Bartholdy, Boris, Todorova, Tihomira I., da Silva Ferreira, Mariana, Chen, Jiahao, Yu, Yiting, Mayer, Jillian, Barreyro, Laura, Carvajal, Luis, Ben Neriah, Daniela, Roth, Michael, van Oers, Johanna, Schaetzlein, Sonja, McMahon, Christine, Edelmann, Winfried, Verma, Amit, Steidl, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5144917/
https://ncbi.nlm.nih.gov/pubmed/26343801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3936
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