IL1RAP potentiates multiple oncogenic signaling pathways in AML

The surface molecule interleukin-1 receptor accessory protein (IL1RAP) is consistently overexpressed across multiple genetic subtypes of acute myeloid leukemia (AML) and other myeloid malignancies, including at the stem cell level, and is emerging as a novel therapeutic target. However, the cell-int...

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Bibliographic Details
Published in:J Exp Med
Main Authors: Mitchell, Kelly, Barreyro, Laura, Todorova, Tihomira I., Taylor, Samuel J., Antony-Debré, Iléana, Narayanagari, Swathi-Rao, Carvajal, Luis A., Leite, Joana, Piperdi, Zubair, Pendurti, Gopichand, Mantzaris, Ioannis, Paietta, Elisabeth, Verma, Amit, Gritsman, Kira, Steidl, Ulrich
Format: Artigo
Language:Inglês
Published: Rockefeller University Press 2018
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5987926/
https://ncbi.nlm.nih.gov/pubmed/29773641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180147
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