TNF regulates transcription of NLRP3 inflammasome components and inflammatory molecules in cryopyrinopathies

The NLRP3 inflammasome is a protein complex responsible for caspase-1–dependent maturation of the proinflammatory cytokines IL-1β and IL-18. Gain-of-function missense mutations in NLRP3 cause the disease spectrum known as the cryopyrin-associated periodic syndromes (CAPS). In this study, we generate...

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Dettagli Bibliografici
Pubblicato in:J Clin Invest
Autori principali: McGeough, Matthew D., Wree, Alexander, Inzaugarat, Maria E., Haimovich, Ariela, Johnson, Casey D., Peña, Carla A., Goldbach-Mansky, Raphaela, Broderick, Lori, Feldstein, Ariel E., Hoffman, Hal M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5707143/
https://ncbi.nlm.nih.gov/pubmed/29130929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI90699
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