An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons

The ubiquitin-proteasome system (UPS) is responsible for most selective protein degradation in eukaryotes and regulates numerous cellular processes, including cell cycle control and protein quality control. A component of this system, the deubiquitinating enzyme USP14, associates with the proteasome...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Boselli, Monica, Lee, Byung-Hoon, Robert, Jessica, Prado, Miguel A., Min, Sang-Won, Cheng, Chialin, Silva, M. Catarina, Seong, Changhyun, Elsasser, Suzanne, Hatle, Ketki M., Gahman, Timothy C., Gygi, Steven P., Haggarty, Stephen J., Gan, Li, King, Randall W., Finley, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5702663/
https://ncbi.nlm.nih.gov/pubmed/28972160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.815126
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