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USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites
USP14 is a major regulator of the proteasome and one of three proteasome-associated deubiquitinating enzymes(1–9). Its effects on protein turnover are substrate specific, for unknown reasons. We report that USP14 shows a dramatic preference for ubiquitin-cyclin B conjugates that carry more than one...
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| 出版年: | Nature |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4844788/ https://ncbi.nlm.nih.gov/pubmed/27074503 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature17433 |
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