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Enhancement of Proteasome Activity by a Small-Molecule Inhibitor of Usp14
Proteasomes, the primary mediators of ubiquitin-protein conjugate degradation, are regulated through complex and poorly understood mechanisms. Here we show that Usp14, a proteasome-associated deubiquitinating enzyme, can inhibit the degradation of ubiquitin-protein conjugates, in vivo and in vitro....
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| Main Authors: | , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2939003/ https://ncbi.nlm.nih.gov/pubmed/20829789 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09299 |
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