Enhancement of Proteasome Activity by a Small-Molecule Inhibitor of Usp14

Proteasomes, the primary mediators of ubiquitin-protein conjugate degradation, are regulated through complex and poorly understood mechanisms. Here we show that Usp14, a proteasome-associated deubiquitinating enzyme, can inhibit the degradation of ubiquitin-protein conjugates, in vivo and in vitro....

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Bibliographische Detailangaben
Hauptverfasser: Lee, Byung-Hoon, Lee, Min Jae, Park, Soyeon, Oh, Dong-Chan, Elsasser, Suzanne, Chen, Ping-Chung, Gartner, Carlos, Dimova, Nevena, Hanna, John, Gygi, Steven P., Wilson, Scott M., King, Randall W., Finley, Daniel
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939003/
https://ncbi.nlm.nih.gov/pubmed/20829789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09299
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