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Substrate degradation by the proteasome: a single-molecule kinetic analysis
To address how the configuration of conjugated ubiquitins determines the recognition of substrates by the proteasome, we analyzed the degradation kinetics of substrates with chemically defined ubiquitin configurations. Contrary to the view that a tetraubiquitin chain is the minimal signal for effici...
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| Pubblicato in: | Science |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4450770/ https://ncbi.nlm.nih.gov/pubmed/25859050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1250834 |
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