Structural basis for dynamic regulation of the human 26S proteasome

The proteasome is the major engine of protein degradation in all eukaryotic cells. At the heart of this machine is a heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitylated target proteins that are concurrently translocated into a proteol...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Chen, Shuobing, Wu, Jiayi, Lu, Ying, Ma, Yong-Bei, Lee, Byung-Hoon, Yu, Zhou, Ouyang, Qi, Finley, Daniel J., Kirschner, Marc W., Mao, Youdong
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2016
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135334/
https://ncbi.nlm.nih.gov/pubmed/27791164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614614113
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