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Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome
The proteasome is an ATP-dependent, 2.5-megadalton machine responsible for selective protein degradation in eukaryotic cells. Here we present cryo-EM structures of the substrate-engaged human proteasome in seven conformational states at 2.8-3.6 Å resolution, captured during breakdown of a polyubiqui...
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| 發表在: | Nature |
|---|---|
| Main Authors: | , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6370054/ https://ncbi.nlm.nih.gov/pubmed/30479383 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0736-4 |
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