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Enhancement of Proteasome Activity by a Small-Molecule Inhibitor of Usp14
Proteasomes, the primary mediators of ubiquitin-protein conjugate degradation, are regulated through complex and poorly understood mechanisms. Here we show that Usp14, a proteasome-associated deubiquitinating enzyme, can inhibit the degradation of ubiquitin-protein conjugates, in vivo and in vitro....
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| 主要な著者: | , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2939003/ https://ncbi.nlm.nih.gov/pubmed/20829789 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09299 |
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