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A High-Throughput Screening Method for Identification of Inhibitors of the Deubiquitinating Enzyme USP14
Deubiquitinating enzymes (DUBs) reverse the process of ubiquitination, and number nearly 100 in humans. In principle, DUBs represent promising drug targets, as several of the enzymes have been implicated in human diseases. The isopeptidase activity of DUBs can be selectively inhibited by targeting t...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3690187/ https://ncbi.nlm.nih.gov/pubmed/23788557 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/9780470559277.ch120078 |
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