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A High-Throughput Screening Method for Identification of Inhibitors of the Deubiquitinating Enzyme USP14

Deubiquitinating enzymes (DUBs) reverse the process of ubiquitination, and number nearly 100 in humans. In principle, DUBs represent promising drug targets, as several of the enzymes have been implicated in human diseases. The isopeptidase activity of DUBs can be selectively inhibited by targeting t...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Lee, Byung-Hoon, Finley, Daniel, King, Randall W.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690187/
https://ncbi.nlm.nih.gov/pubmed/23788557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/9780470559277.ch120078
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