Autophagy-independent lysosomal targeting regulated by ULK1/2-FIP200 and ATG9

Iron is vital for many homeostatic processes and its liberation from ferritin nanocages occurs in the lysosome. Studies indicate that ferritin and its binding partner nuclear receptor coactivator-4 (NCOA4) are targeted to lysosomes by a form of selective autophagy. By using genome-scale functional s...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Goodwin, Jonathan M., Dowdle, William E., DeJesus, Rowena, Wang, Zuncai, Bergman, Philip, Kobylarz, Marek, Lindeman, Alicia, Xavier, Ramnik, McAllister, Gregory, Nyfeler, Beat, Hoffman, Gregory, Murphy, Leon O.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5699710/
https://ncbi.nlm.nih.gov/pubmed/28877469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.08.034
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