Autophagy-independent lysosomal targeting regulated by ULK1/2-FIP200 and ATG9

Iron is vital for many homeostatic processes and its liberation from ferritin nanocages occurs in the lysosome. Studies indicate that ferritin and its binding partner nuclear receptor coactivator-4 (NCOA4) are targeted to lysosomes by a form of selective autophagy. By using genome-scale functional s...

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Udgivet i:Cell Rep
Main Authors: Goodwin, Jonathan M., Dowdle, William E., DeJesus, Rowena, Wang, Zuncai, Bergman, Philip, Kobylarz, Marek, Lindeman, Alicia, Xavier, Ramnik, McAllister, Gregory, Nyfeler, Beat, Hoffman, Gregory, Murphy, Leon O.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5699710/
https://ncbi.nlm.nih.gov/pubmed/28877469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.08.034
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