Internalization of the Active Subunit of the Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin Is Dependent upon Cellugyrin (Synaptogyrin 2), a Host Cell Non-Neuronal Paralog of the Synaptic Vesicle Protein, Synaptogyrin 1

The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) is a heterotrimeric AB(2) toxin capable of inducing lymphocytes, and other cell types, to undergo cell cycle arrest and apoptosis. Exposure to Cdt results in binding to the cell surface followed by internalization and transl...

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Détails bibliographiques
Publié dans:Front Cell Infect Microbiol
Auteurs principaux: Boesze-Battaglia, Kathleen, Walker, Lisa P., Dhingra, Anuradha, Kandror, Konstantin, Tang, Hsin-Yao, Shenker, Bruce J.
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2017
Sujets:
Microbiology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5694546/
https://ncbi.nlm.nih.gov/pubmed/29184850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2017.00469
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